BIG issue with manufactured chemical fertilizers is "How much is enough"? Nice thing about compost and such if allowed to age (no fresh horse manure type thing) is that one cannot really "over" compost (though pure compost does hold a lot of water, so drainage can be an issue). But with chemical fertilizers one can kill a plant if too much used.
Too little and you lose the growth potential, too much and you can kill it. Hitting the happy balance is not easy, especially with all the variables - size of plan t (which keeps getting larger so more needed, but how much more :-), soil conditions, leaching, etc.
Experience seems to be the best quide, but takes time, so back to how much is enough for the chemical (manufactured) approach.